منابع مشابه
Neuromuscular Blockers PHYSIOLOGY OF NEUROMUSCULAR TRANSMISSION Anatomy of the Neuromuscular Junction
the structure was established by King in 1935, however, one of the nitrogen groups was later found to be tertiary a synthetic analogue, metocurine, was developed several years later with 3x the potency of dTC gallamine, another of the series, was synthesised about 1950 NB: in 1954 Beecher & Todd published their multi-institutional report which showed a 6-fold increase in mortality with the use ...
متن کاملThe neuromuscular junction disorders.
Neuromuscular junction (NMJ) disorders result from destruction, malfunction or absence of one or more key proteins involved in neuromuscular transmission, illustrated diagrammatically in fig 1. The most common pathology is antibody mediated damage or down regulation of ion channels or receptors, resulting in myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and acquired neuromyo...
متن کاملThe Neuromuscular Junction
If such a nerve fiberwere to be directly joined to amuscle fiber of, say, 50μmin diameter, then as the propagating action potential reached the nerve–muscle junction, the local circuit current density set up in the muscle would be considerably reduced from that in the nerve. This reduction would occur because the nerve and muscle must have the same total current, a consequence of current conser...
متن کاملPathology of the neuromuscular junction.
Diagnosis of neuromuscular disease by the study of motor endplate structure in the light and electron microscopes is probably one of the most specialized examinations in the field of neuropathology. The classical means of staining endplates using gold, silver or methylene blue are described as well as more modern techniques suitable for light microscopy. Specific abnormalities in patterns of te...
متن کاملDevelopment of the Neuromuscular Junction
Development of the neuromuscular junction on differentiating muscle was investigated in the regenerating limb of the newt Triturus. Motor end-plate formation begins when vesicle-filled axon terminations approach differentiating muscle cells that have reached the stage of a multinucleate cell containing myofibrils. Slight ridges or elevations occur on the muscle surface, and there is an increase...
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ژورنال
عنوان ژورنال: BJA CEPD Reviews
سال: 2002
ISSN: 1472-2615
DOI: 10.1093/bjacepd/02.05.129